Transfer RNA-derived fragments: origins, processing, and functions
نویسندگان
چکیده
منابع مشابه
Characterization of circulating transfer RNA-derived RNA fragments in cattle
The objective was to characterize naturally occurring circulating transfer RNA-derived RNA fragments (tRFs) in cattle. Serum from eight clinically normal adult dairy cows was collected, and small non-coding RNAs were extracted immediately after collection and sequenced by Illumina MiSeq. Sequences aligned to transfer RNA (tRNA) genes or their flanking sequences were characterized. Sequences ali...
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We have created tRFdb, the first database of transfer RNA fragments (tRFs), available at http://genome.bioch.virginia.edu/trfdb/. With over 100 small RNA libraries analyzed, the database currently contains the sequences and read counts of the three classes of tRFs for eight species: R. sphaeroides, S. pombe, D. melanogaster, C. elegans, Xenopus, zebra fish, mouse and human, for a total of 12,87...
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tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the...
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Four recent studies suggest that cleavages of transfer RNAs generate products with microRNA-like features, with some evidence of function. If their regulatory functions were to be confirmed, these newly revealed RNAs would add to the expanding repertoire of small noncoding RNAs and would also provide new perspectives on the coevolution of transfer RNA and messenger RNA.
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“Place” is an important concept providing a useful dimension to explore, align and analyze data on the Linked Data Web. ough Linked Data datasets can use standardized geospatial predicates such as GeoSPARQL, access to SPARQL endpoints that supports these is not guaranteed. When not available, one needs to load the data into their own GeoSPARQL-enabled triplestores in order to avail of those pr...
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: RNA
سال: 2011
ISSN: 1757-7004
DOI: 10.1002/wrna.96